By coincidence, there is an article in the current issue of MEW (April 2011, no. 175) by a chap who had the same problem with a 4" Pratt-Bernerd. He made new screws from 1/2 x 1.25" Whit hex socket grubscrews, and a hex chuck key to operate them. He doesn't say where he sourced the grubscrews. Of course, your larger chuck may use a larger size of screw.
Andy