Hi Geoff,
The short answer is as little as possible.
These types of coupler are intended to allow for a small amount of angular and very little or no radial misalignment. If you have just angular misalignment, then bellows type couplings might be better. Bellows type won't allow any backlash either. Don't forget the insert is flexible and will introduce backlash, particularly if the loading is high.
If I were using direct drive from a stepper or servo motor, I would use a rigid coupling and make the mounting holes slightly oversize so the you can align the shafts accurately. If necessary using pined plates to fix the screw hole locations.
HTH.